MASLD pathophysiology

Clinical Definition Fatty Liver Disease, increasingly referred to as Steatotic Liver Disease (SLD), is defined histologically by the accumulation of excess macrovesicular fat (triglycerides) in >5% of hepatocytes. It is clinically categorized into Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD/NAFLD), driven by insulin resistance and metabolic syndrome, and Alcohol-Associated Liver Disease (ALD). The condition exists on…