Leukemia (Hematologic Malignancies): Classification, Bone Marrow Biopsy & Cytogenetics
Clinical Definition Leukemia represents a heterogeneous group of malignant neoplasms arising from the hematopoietic stem cells within the bone marrow. It is characterized by the uncontrolled proliferation and accumulation of immature, dysfunctional leukocytes (blasts) or mature but abnormal white blood cells. This clonal expansion disrupts normal hematopoiesis, leading to the suppression of erythroid, myeloid, and…