Biguanide

Pharmacological Classification Class: Biguanide ATC Code: A10BA02 Mechanism of Action (MOA) Metformin’s primary antihyperglycemic effect is achieved through the activation of AMP-activated protein kinase (AMPK), a key enzyme in cellular energy homeostasis. This activation leads to several downstream effects. In the liver, it inhibits hepatic gluconeogenesis and glycogenolysis, effectively reducing the endogenous production of glucose….